Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine
Identifieur interne : 000B48 ( Main/Exploration ); précédent : 000B47; suivant : 000B49Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine
Auteurs : CHAO QIU [République populaire de Chine] ; YANG HUANG [République populaire de Chine] ; QIAN WANG [République populaire de Chine] ; DI TIAN [République populaire de Chine] ; WANJU ZHANG [République populaire de Chine] ; YUNWEN HU [République populaire de Chine] ; ZHENGHONG YUAN [République populaire de Chine] ; XIAOYAN ZHANG [République populaire de Chine] ; JIANQING XU [République populaire de Chine]Source :
- Clinical infectious diseases [ 1058-4838 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Background. A mass vaccination has been implemented to prevent the spread of 2009 pandemic influenza virus in China. Highly limited information is available on whether this vaccine induces cross-reactive neutralization antibodies against other subtypes of influenza viruses. Methods. We employed pseudovirus-based assays to analyze heterosubtypic neutralization responses in serum samples of 23 recipients of 2009 pandemic influenza vaccine. Results. One dose of pandemic vaccine not only stimulated good neutralization antibodies against cognate influenza virus 2009 influenza A (H1N1), but also raised broad cross-reactive neutralization activities against seasonal H3N2 and highly pathogenic avian influenza virus H5N1 and lesser to H2N2. The cross-reactive neutralization activities were completely abolished after the removal of immunoglobin G (IgG). In contrast, H1N1 vaccination alone in influenza-naive mice elicited only vigorous homologous neutralizing activities but not cross-reactive neutralization activities. Conclusions. Our data suggest that the cross-reactive neutralization epitopes do exist in this vaccine and could elicit significant cross-reactive neutralizing IgG antibodies in the presence of preexisting responses. The exposure to H1N1 vaccine is likely to modify the hierarchical order of preexisting immune responses to influenza viruses. These findings provide insights into the evolution of human immunity to influenza viruses after experiencing multiple influenza virus infections and vaccinations.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000006
- to stream PascalFrancis, to step Curation: 000068
- to stream PascalFrancis, to step Checkpoint: 000006
- to stream Main, to step Merge: 000B51
- to stream Main, to step Curation: 000B48
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine</title><author><name sortKey="Chao Qiu" sort="Chao Qiu" uniqKey="Chao Qiu" last="Chao Qiu">CHAO QIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Yang Huang" sort="Yang Huang" uniqKey="Yang Huang" last="Yang Huang">YANG HUANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>VacDiagn Biotechnology</s1><s2>Suzhou</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>VacDiagn Biotechnology</wicri:noRegion></affiliation></author><author><name sortKey="Qian Wang" sort="Qian Wang" uniqKey="Qian Wang" last="Qian Wang">QIAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>VacDiagn Biotechnology</s1><s2>Suzhou</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>VacDiagn Biotechnology</wicri:noRegion></affiliation></author><author><name sortKey="Di Tian" sort="Di Tian" uniqKey="Di Tian" last="Di Tian">DI TIAN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wanju Zhang" sort="Wanju Zhang" uniqKey="Wanju Zhang" last="Wanju Zhang">WANJU ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Yunwen Hu" sort="Yunwen Hu" uniqKey="Yunwen Hu" last="Yunwen Hu">YUNWEN HU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Zhenghong Yuan" sort="Zhenghong Yuan" uniqKey="Zhenghong Yuan" last="Zhenghong Yuan">ZHENGHONG YUAN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Xiaoyan Zhang" sort="Xiaoyan Zhang" uniqKey="Xiaoyan Zhang" last="Xiaoyan Zhang">XIAOYAN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Jianqing Xu" sort="Jianqing Xu" uniqKey="Jianqing Xu" last="Jianqing Xu">JIANQING XU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0165222</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0165222 INIST</idno><idno type="RBID">Pascal:12-0165222</idno><idno type="wicri:Area/PascalFrancis/Corpus">000006</idno><idno type="wicri:Area/PascalFrancis/Curation">000068</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000006</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000006</idno><idno type="wicri:doubleKey">1058-4838:2012:Chao Qiu:boosting:heterosubtypic:neutralization</idno><idno type="wicri:Area/Main/Merge">000B51</idno><idno type="wicri:Area/Main/Curation">000B48</idno><idno type="wicri:Area/Main/Exploration">000B48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine</title><author><name sortKey="Chao Qiu" sort="Chao Qiu" uniqKey="Chao Qiu" last="Chao Qiu">CHAO QIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Yang Huang" sort="Yang Huang" uniqKey="Yang Huang" last="Yang Huang">YANG HUANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>VacDiagn Biotechnology</s1><s2>Suzhou</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>VacDiagn Biotechnology</wicri:noRegion></affiliation></author><author><name sortKey="Qian Wang" sort="Qian Wang" uniqKey="Qian Wang" last="Qian Wang">QIAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>VacDiagn Biotechnology</s1><s2>Suzhou</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>VacDiagn Biotechnology</wicri:noRegion></affiliation></author><author><name sortKey="Di Tian" sort="Di Tian" uniqKey="Di Tian" last="Di Tian">DI TIAN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wanju Zhang" sort="Wanju Zhang" uniqKey="Wanju Zhang" last="Wanju Zhang">WANJU ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Yunwen Hu" sort="Yunwen Hu" uniqKey="Yunwen Hu" last="Yunwen Hu">YUNWEN HU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Zhenghong Yuan" sort="Zhenghong Yuan" uniqKey="Zhenghong Yuan" last="Zhenghong Yuan">ZHENGHONG YUAN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Xiaoyan Zhang" sort="Xiaoyan Zhang" uniqKey="Xiaoyan Zhang" last="Xiaoyan Zhang">XIAOYAN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Jianqing Xu" sort="Jianqing Xu" uniqKey="Jianqing Xu" last="Jianqing Xu">JIANQING XU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Clinical infectious diseases</title><title level="j" type="abbreviated">Clin. infect. dis.</title><idno type="ISSN">1058-4838</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical infectious diseases</title><title level="j" type="abbreviated">Clin. infect. dis.</title><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term><term>Booster effect</term><term>H1N1 influenza</term><term>Human</term><term>Immunoprophylaxis</term><term>Infection</term><term>Neutralization</term><term>Prevention</term><term>Recipient</term><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Immunoprophylaxie</term><term>Neutralisation</term><term>Anticorps</term><term>Receveur</term><term>Homme</term><term>Vaccin</term><term>Prévention</term><term>Infection</term><term>Effet booster</term><term>Grippe H1N1</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. A mass vaccination has been implemented to prevent the spread of 2009 pandemic influenza virus in China. Highly limited information is available on whether this vaccine induces cross-reactive neutralization antibodies against other subtypes of influenza viruses. Methods. We employed pseudovirus-based assays to analyze heterosubtypic neutralization responses in serum samples of 23 recipients of 2009 pandemic influenza vaccine. Results. One dose of pandemic vaccine not only stimulated good neutralization antibodies against cognate influenza virus 2009 influenza A (H1N1), but also raised broad cross-reactive neutralization activities against seasonal H3N2 and highly pathogenic avian influenza virus H5N1 and lesser to H2N2. The cross-reactive neutralization activities were completely abolished after the removal of immunoglobin G (IgG). In contrast, H1N1 vaccination alone in influenza-naive mice elicited only vigorous homologous neutralizing activities but not cross-reactive neutralization activities. Conclusions. Our data suggest that the cross-reactive neutralization epitopes do exist in this vaccine and could elicit significant cross-reactive neutralizing IgG antibodies in the presence of preexisting responses. The exposure to H1N1 vaccine is likely to modify the hierarchical order of preexisting immune responses to influenza viruses. These findings provide insights into the evolution of human immunity to influenza viruses after experiencing multiple influenza virus infections and vaccinations.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chao Qiu" sort="Chao Qiu" uniqKey="Chao Qiu" last="Chao Qiu">CHAO QIU</name></noRegion><name sortKey="Chao Qiu" sort="Chao Qiu" uniqKey="Chao Qiu" last="Chao Qiu">CHAO QIU</name><name sortKey="Di Tian" sort="Di Tian" uniqKey="Di Tian" last="Di Tian">DI TIAN</name><name sortKey="Jianqing Xu" sort="Jianqing Xu" uniqKey="Jianqing Xu" last="Jianqing Xu">JIANQING XU</name><name sortKey="Jianqing Xu" sort="Jianqing Xu" uniqKey="Jianqing Xu" last="Jianqing Xu">JIANQING XU</name><name sortKey="Qian Wang" sort="Qian Wang" uniqKey="Qian Wang" last="Qian Wang">QIAN WANG</name><name sortKey="Wanju Zhang" sort="Wanju Zhang" uniqKey="Wanju Zhang" last="Wanju Zhang">WANJU ZHANG</name><name sortKey="Xiaoyan Zhang" sort="Xiaoyan Zhang" uniqKey="Xiaoyan Zhang" last="Xiaoyan Zhang">XIAOYAN ZHANG</name><name sortKey="Xiaoyan Zhang" sort="Xiaoyan Zhang" uniqKey="Xiaoyan Zhang" last="Xiaoyan Zhang">XIAOYAN ZHANG</name><name sortKey="Yang Huang" sort="Yang Huang" uniqKey="Yang Huang" last="Yang Huang">YANG HUANG</name><name sortKey="Yunwen Hu" sort="Yunwen Hu" uniqKey="Yunwen Hu" last="Yunwen Hu">YUNWEN HU</name><name sortKey="Zhenghong Yuan" sort="Zhenghong Yuan" uniqKey="Zhenghong Yuan" last="Zhenghong Yuan">ZHENGHONG YUAN</name><name sortKey="Zhenghong Yuan" sort="Zhenghong Yuan" uniqKey="Zhenghong Yuan" last="Zhenghong Yuan">ZHENGHONG YUAN</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B48 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B48 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0165222
|texte= Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine
}}
| This area was generated with Dilib version V0.6.33. |  |